Nephrotoxic Evaluation of Aqueous Stem Bark Extract of Dialium guineense in Normal Wistar Rats

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Published: Sep 17, 2022
DOI: https://doi.org/10.47191/ijpbms/v2-i9-04
Keywords:
Dialium guineense, Electrolytes, Graded doses, Nephrotoxic effect, Urea.

Main Article Content

Abu O.D.
Department of Biochemistry, Faculty of Life Sciences, University of Benin, Benin City, Nigeria.
Onoagbe I.O.
Department of Biochemistry, Faculty of Life Sciences, University of Benin, Benin City, Nigeria.
Ekugum E.
Department of Pharmaceutical Technology, Edo State Polytechnic, Usen, Edo State, Nigeria.

Abstract

The present study investigated the nephrotoxic effect of aqueous extract of Dialium guineense stem bark in normal Wistar albino rats. Thirty-five male rats were used. Graded doses of the extract ranging from 200 to 5000 mg/kg body weight, bwt, were administered to the test rats daily for twenty-eight days. The control rats received distilled water. Thereafter plasma levels of creatinine, urea, electrolytes and urease activity were determined. There were no significant differences in the concentrations of the measured renal parameters, when compared with control group (p > 0.05). These results appear to suggest that the extract may be safe at concentrations not exceeding 5000 mg/kg bwt. However, further studies spanning several months may be necessary.          

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How to Cite
Abu O.D., Onoagbe I.O., & Ekugum E. (2022). Nephrotoxic Evaluation of Aqueous Stem Bark Extract of Dialium guineense in Normal Wistar Rats. International Journal of Pharmaceutical and Bio Medical Science, 2(9), 353–357. https://doi.org/10.47191/ijpbms/v2-i9-04
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Vol. 2 No. 9 (2022): Volume 02 Issue 09 September 2022
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Articles
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This work is licensed under a Creative Commons Attribution 4.0 International License.

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