“FLAG” Tag Sequenced E-Protein Marker Demonstrating Tetravalent Dengue Virus Like Particles (DENV-Lps) As Potential Vaccine Candidate
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Abstract
Dengue is a very deadly virus. It causes viral infections that are transmitted to humans through a small bite of specific mosquitoes. These mosquitoes are generally infected. The main primary vector of this deadly disease is Aedes aegypti mosquitoes. This virus is generally called the dengue virus or DENV. It is a single-stranded RNA virus. Due to this dengue virus causes deadly and hazardous infections. It mainly occurs in various tropical and subtropical regions. Dengue causes a very broad range of diseases, sometimes making the detection of symptoms quite hard. There are numerous causes that are directly and indirectly linked to the growth of the dengue virus in the environment. The symptoms may vary from simple flu to deadly fever. And till date, there is no specific treatment for dengue. In many countries especially the tropical regions, there has been a huge number of deaths from this DENV virus. The complicated pathogenesis of this deadly virus has been a constant barrier for scientists to discover a medicine or vaccine for this disease. Dengue virus falls under the family of Flaviviridae. It has four different types of serotypes present in it. Those are DENV-1, DENV-2, DENV-3, and DENV-4. The epidemiological patterns of these four serotypes are interlinked with each other. They can co-circulate among each other and can create severe to very severe infections. The most respectful nature of DENV is that it transmits from one person to another by various means. Though it is quite rare it is possible of creating local transmissions.
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