Internal Standard an Important Analyte Use in Drug Analysis by Liquid Chromatography Mass Spectrometry- An Article

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Published: Jan 11, 2022
DOI: https://doi.org/10.47191/ijpbms/v2-i1-02
Keywords:
LC-MS/MS, Internal standard, Drug analysis

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Pallab Mandal
TAAB Biostudy Services, Jadavpur, Kolkata 700032, India Bioequivalence Study Centre, Department of Pharmaceutical Technology, Jadavpur University Kolkata, India Department of Pharmaceutical Technology, Jadavpur University , Kolkata, India
Soumya Chakraborty
TAAB Biostudy Services, Jadavpur, Kolkata 700032, India College of Pharmaceutical Sciences, Mohuda, Berhampore, Orissa, India
Rakesh Bera
TAAB Biostudy Services, Jadavpur, Kolkata 700032, India Bharat Technology, Uluberia, Howrah, India
Sanmoy Karmakar
Bioequivalence Study Centre, Department of Pharmaceutical Technology, Jadavpur University Kolkata, India Department of Pharmaceutical Technology, Jadavpur University , Kolkata, India
Tapan Kumar Pal
TAAB Biostudy Services, Jadavpur, Kolkata 700032, India Bioequivalence Study Centre, Department of Pharmaceutical Technology, Jadavpur University Kolkata, India Department of Pharmaceutical Technology, Jadavpur University , Kolkata, India

Abstract

Internal standard is an external compound which is mixed with targeted analytical solution and matrix as a constant concentration and use for preparing calibration standard curve by using ratio of analyte area and internal standard area with analyte concentration and internal standard concentration. This calibration curve used for quantification of unknown concentration of anlayte of interest. This article provide necessary information about internal standard like its selection procedure, characterization, types and response factor , to all analyst who are connected with drug analysis. This article is more important and I think first article which focuses a clear idea about internal standard use in drug analysis.

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How to Cite
Mandal, P. ., Chakraborty, S. ., Bera, R. ., Karmakar, S. ., & Pal, T. K. . (2022). Internal Standard an Important Analyte Use in Drug Analysis by Liquid Chromatography Mass Spectrometry- An Article. International Journal of Pharmaceutical and Bio Medical Science, 2(01), 10–17. https://doi.org/10.47191/ijpbms/v2-i1-02
Issue
Vol. 2 No. 01 (2022): Volume 02 Issue 01 January 2022
Section
Articles
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This work is licensed under a Creative Commons Attribution 4.0 International License.

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