Correlation of Selenium Level, Malondialdehyde (MDA) and Total antioxidant Status (TAS), with Thyroid Hormones in Hypothyroidism Women
Main Article Content
Abstract
Background and objective: The thyroid gland and its hormones are crucial for the development of the body's organs as well as the balanced regulation of the body's fundamental physiological processes and . One of the most prevalent thyroid conditions in adults is hypothyroidism, often known as myxedema. The study's objective was to discover thyroid hormones in women with hypothyroidism, including selenium levels, malondialdehyde (MDA), and total antioxidant status (TAS), since these indicators may suggest thyroid health.
Materials and Methods: In this case-control research, which comprised 70 hypothyroid women and 30 controls who appeared to be in good health, the participants' ages varied from 20 to over 40. People who attended the laboratory at Imam Al-Sadiq Hospital and Merjan General Hospital were selected as hypothyroid patients.The serum concentrations Selenium Levels, Malondialdehyde (MDA) and Total antioxidant Status (TAS), total triiodothyronine (T3), total thyroxin (T4), thyroid stimulating hormones (TSH), were measured in 100 samples, mini-vidas were employed for T3,T4,TSH measurment. while Electrofluorescence immunoassay was used to measure the , Malondialdehyde (MDA) and Total antioxidant Status (TAS), levels Selenium and concentration.
Results : TSH levels 22.73 nmol/L were significantly higher (P < 0.05) in hypothyroid patients compared to controls 1.77 nmol/L, while levels of T3 1.41 nmol/L and T4 55.22 nmol/L were significantly lower (P < 0.05). In hypothyroid patients compared with the control group 2.08 nmol/L, 81.81 nmol/L respectively while malondialdehyde (MDA) levels were 35.16±2.2 (ng/ml ) Significantly higher ≤0.0001) in women with hypothyroidism and total antioxidant status (TAO) 175.07±3.8 (mg AAAE/ml) There was a significant reduction in Total antioxidant status as well as selenium concentration was 12.14±0.9 (ng/ml) (P < 0.011) among women with hypothyroidism and healthy women, respectively.
Conclusion: People with hypothyroidism who are potentially at risk for thyroid problems may be better detected in women who have lower selenium levels and total antioxidant status with significantly higher malondialdehyde (MDA) levels
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