The Impact of IL-4 on Abortion Rates in Iraqi Women's Last Trimester Pregnancies

Abstract

The term "abortion" is used to describe the termination of a pregnancy through the surgical expulsion of a developing embryo or fetus. Whole samples were collected from Al-Zahraa Teaching Hospital in Wasit city From mid-October 2022 until mid-October 2023. The total number of samples was 100 divided into two groups: the first group is women who suffer from a miscarriage in the third  trimester and the control group .Result: This table shows the interpretation of the results between patients and healthy people, where the homozygous CC genotype significantly decreased comparing with control (64 versus 86%, OR=0.18; p-value =0.03 ), while the CT heterozygous genotype  was significantly high with risk in comparison with control (32 versus 8%; OR= 7.3; p-value 0.005). The study of polymorphism of the IL-4 gene and its association with abortion had limited available data. This study is the second to report on the association between polymorphism of IL-4 and abortion. showed a clear difference of the parameter’s levels in abortion study group. Based on the mutant homozygous CC genotype. In the present study, the significant change in IL-4 concentration was observed due to the effect of the polymorphism in cases of abortion. These findings were consistent with a previous study that reported higher concentrations of IL-4 in women with abortion compared to normal women (P-value of 0.001). (Association between maternal circulating IL-4 levels and preeclampsia).