Formulation and Evaluation of Bilayer Anti-Diabetic Tablet of Murayya Koeinigii and Spinach Olaracea
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Abstract
The purpose of this study was to develop and evaluate bilayer tablet for the immediate and controlled release of murayya koeinigii and spinach oleracea for effective treatment of diabeties (Type 2). The immediate release layer was prepared by using super disintegrants- starch powder and the sustained release layer was prepared by using polymer like acaia, HPMC E5 and Methyl cellulose. Before preparation of the tablets, all the preformulation parameters were checked and the tablet of murayya koeinigii and spinach oleracea were prepared by direct compression method and was evaluated for physical characteristics like hardness, weight variation, drug content and friability. In vitro release of drug was performed USP type II dissolution test apparatus using distilled water buffer as dissolution media and dissolution was continued for 10 hrs for the sustained release layer. It was found that all the formulations were within the limit of the standard. The drug release of the tablet was in the range of 67%-99% in 10 h. The drug release pattern of formulation F5 was fitted in different kinetic models which showed highest regression for zero order kinetics with Koresmeyer Peppas through non-fickian type of drug release mechanism. Hence It was concluded that the F5 formulation showed the optimum result as a bilayer tablet for the effective treatment of diabeties (Type 2).
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