A Comprehensive Review on Role of Polymers in Transdermal Drug Delivery System
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Abstract
Transdermal drug delivery system has been emerged as one of the most effective controlled drug release system in topical formulation as it doesn’t undergo first pass metabolism in liver and can be directly absorbed into the systemic circulation. Polymers are used in TDDS as to increase its effectiveness in the control release of drug from the transdermal patch. Use of polymers in the TDDS has decreased the control release rate of drug from the patch. Use of polymers in combination has given more effectiveness of the drug release. This article gives a quality of information about the use of polymers in the Transdermal drug delivery system. Polymers also help in the adhesive nature of the drug to the skin and promote more extent of drug release from the dosage form. An advance in the use and amount of polymers used in the TDDS has been increased recently. This article provides the information about the use of Natural, semisynthetic and synthetic polymers in the TDDS. Use of natural polymers has been showed more impact in the TDDS and their use has showed fewer side effects like irritation, allergy, and this has been increased patient compliance and more effectiveness in drug release. Semisynthetic and synthetic polymers has been developed and used excessively in the TDDS for effective control release of the drug from the patches. A transdermal patch is defined as medicated adhesive patch which is placed above the skin to deliver a pre-determined dose of medication via skin with a predetermined rate of release to reach into the bloodstream.
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