Antinociceptive Effect of Ethanol Extract of Physalis Angulata
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Abstract
Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. Pain is the most common reason a patient sees a physician. However, conventional painkillers are not completely effective in controlling all pain syndromes; thus, additional efforts have been made to develop analgesic drugs from natural materials. In this study, the ethanolic extract of Physalis angulata (EEA) was examined for its antinociceptive activity at doses of 140, 280, and 560 mg/kg body weight. Acetic acid-induced writhing was used to evaluate the antinociceptive activity of EEPa. The results showed that the EEPa (140, 280, and 560 mg/kg BW) had significant antinociceptive activity. The percentage of inhibition was 29,41%, 37,96%, 44,38%, respectively. These findings suggest that Physalis angulata leaves extracts possess promising antinociceptive effects.
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