The Role of Color Doppler Ultrasonography in the Prevention of Thromboembolic Disease after Total Hip Replacement

Main Article Content

Hadi Farhat
Prof. Dr. PhD. Fadi Abdel Sater
Edwin Parra Prada
Prof. Dr. Khodor Haidar Hasan

Abstract

Orthopedic and trauma surgery carries a high risk of deep vein thrombosis (DVT) in the lower limbs and acute pulmonary embolism (APE). In traumatology, the greatest risk is in hip fractures of the proximal extremity of the femur, especially those of the neck, and intertrochanteric fractures. In orthopedics the risk of thromboembolic complications (TEC) is particularly high in hip and knee surgery, especially in prosthetic replacement, as general factors are associated with local factors such as trauma to vessels and / or blood stasis which further aggravate the perioperative imbalance of the coagulation system. In particular, hip replacement surgery is the one that shows a higher frequency of DVT (especially affecting the proximal large vessels), and of TEC, so much so that pulmonary embolism is one of the main causes of death after this intervention. In this paper, we review the different instruments used for the diagnosis of DVT such as phlebography, radiolabeled fibrinogen collection test, impedance, plethysmography, ultrasound, nuclear magnetic resonance and computed tomography. We also discuss the different prophylaxis methods for DVT and subsequent PE prevention. Then, we performed an experimental study on 420 patient’s operated on for total hip replacement at the 1st Orthopedic Clinic of the University of Florence and other private clinics in the period between 1994-1996. These are 286 first cemented implants, 36 first hybrid implants, 38 first cementless implants and 60 hip replacement reviews. This study showed the importance of color doppler ultrasonography in the prevention of DVT in hip replacement patients and subsequent APE prophylaxis. Significant relationship was found between APE and the protocole used to follow up with the patients (Pvalue 0.0007). Patients in group 2 in which only clinical control (no preoperative color doppler ultrasonography assessment) was performed have higher risk for APE To Occur Than patients in group 1 to whom pre and post-operative color doppler ultrasonography was routinely applied.

Article Details

How to Cite
Farhat, H. ., Sater, P. D. P. F. A. ., Prada, E. P. ., & Hasan, P. D. K. H. . (2022). The Role of Color Doppler Ultrasonography in the Prevention of Thromboembolic Disease after Total Hip Replacement. International Journal of Pharmaceutical and Bio Medical Science, 2(07), 191–205. https://doi.org/10.47191/ijpbms/v2-i7-02
Section
Articles

References

I. Lin, Patrick P., et al. "Deep venous thrombosis after orthopedic surgery in adult cancer patients." Journal of surgical oncology 68.1 (1998): 41-47.

II. Nick, Alpa M., et al. "Risk of Thromboembolic Disease in Patients Undergoing Laparoscopic Gynecologic Surgery." Obstetrics and Gynecology (New York. 1953), vol. 116, no. 4, 2010, pp. 956-961.

III. Jimenez, David, et al. "Prognostic significance of deep vein thrombosis in patients presenting with acute symptomatic pulmonary embolism." American journal of respiratory and critical care medicine 181.9 (2010): 983-991.

IV. Agnelli, Giancarlo, and Cecilia Becattini. "Acute pulmonary embolism." New England Journal of Medicine 363.3 (2010): 266-274.

V. Wang, Hu, et al. "Perioperative incidence and locations of deep vein thrombosis following specific isolated lower extremity fractures." Injury 49.7 (2018): 1353-1357.

VI. Mula, Viswanath, et al. "Venous thromboembolism rates after hip and knee arthroplasty and hip fractures." BMC musculoskeletal disorders 21.1 (2020): 1-7.

VII. Husted, Henrik, et al. "Low risk of thromboembolic complications after fast-track hip and knee arthroplasty." Acta orthopaedica 81.5 (2010): 599-605.

VIII. Zhou, Xindie, et al. "Who are at risk for thromboembolism after arthroplasty? A systematic review and meta-analysis." Thrombosis research 132.5 (2013): 531-536.

IX. Kashuk, Jeffry L., et al. "Progressive postinjury thrombocytosis is associated with thromboembolic complications." Surgery 148.4 (2010): 667-675.

X. Memtsoudis, Stavros G., et al. "Risk factors for pulmonary embolism after hip and knee arthroplasty: a population-based study." International orthopaedics 33.6 (2009): 1739-1745.

XI. Ryan, Michael G., et al. "Effect of mechanical compression on the prevalence of proximal deep venous thrombosis as assessed by magnetic resonance venography." JBJS 84.11 (2002): 1998-2004.

XII. Kim, John YS, et al. "Surgical duration and risk of venous thromboembolism." JAMA surgery 150.2 (2015): 110-117.

XIII. Sharrock, Nigel E., et al. "Factors Influencing Deep Vein Thrombosis Following Total Hip Arthroplasty Under Epidural Anesthesia." Anesthesia and Analgesia, vol. 76, no. 4, 1993, pp. 765-771.

XIV. Basques, Bryce A., et al. "General compared with spinal anesthesia for total hip arthroplasty." The Journal of bone and joint surgery. American volume 97.6 (2015): 455.

XV. Raskob, Gary E., et al. "Surveillance for Deep Vein Thrombosis and Pulmonary Embolism: Recommendations from a National Workshop." American Journal of Preventive Medicine, vol. 38, no. 4, 2010, pp. S502-S509.

XVI. Toker, Serdar, David J. Hak, and Steven J. Morgan. "Deep vein thrombosis prophylaxis in trauma patients." Thrombosis 2011 (2011).

XVII. Caprini, Joseph A. "Risk assessment as a guide for the prevention of the many faces of venous thromboembolism." The American Journal of Surgery 199.1 (2010): S3-S10.

XVIII. Phan, Kevin, et al. "Anesthesia duration as an independent risk factor for early postoperative complications in adults undergoing elective ACDF." Global spine journal 7.8 (2017): 727-734.

XIX. Felder, Seth, et al. "Prolonged thromboprophylaxis with low molecular weight heparin for abdominal or pelvic surgery." Cochrane Database of Systematic Reviews 8 (2019).

XX. Lee, Seung Yeol, et al. "Incidence of deep vein thrombosis after major lower limb orthopedic surgery: analysis of a nationwide claim registry." Yonsei medical journal 56.1 (2015): 139-145.

XXI. Kory, Pierre D., et al. "Accuracy of ultrasonography performed by critical care physicians for the diagnosis of DVT." Chest 139.3 (2011): 538-542.

XXII. Broen, Kelly, Brian Scholtes, and Renée Vossen. "Predicting the need for further thrombosis diagnostics in suspected DVT is increased by using age adjusted D-dimer values." Thrombosis research 145 (2016): 107-108.

XXIII. Tamura, Kiyoshi, and Hideki Nakahara. "MR venography for the assessment of deep vein thrombosis in lower extremities with varicose veins." Annals of vascular Diseases 7.4 (2014): 399-403.

XXIV. Ho, Vincent B., et al. "ACR Appropriateness Criteria® on suspected lower extremity deep vein thrombosis." Journal of the American College of Radiology 8.6 (2011): 383-387.

XXV. KAMIDA, CURTIS B., et al. "Lower extremity ascending and descending phlebography." Handbook of Venous Disorders: Guidelines of the American Venous Forum Third Edition. CRC Press, 2008.

XXVI. Pieri, A., et al. "Filtres caves temporaires: notre expérience analyse préliminaire de 24 cas." Phlébologie 46.3 (1993): 457-466.

XXVII. Houshmand, Sina, et al. "The role of molecular imaging in diagnosis of deep vein thrombosis." American journal of nuclear medicine and molecular imaging 4.5 (2014): 406.

XXVIII. Eu, Peter. "An Update on the Detection of Deep Vein Thrombosis."

XXIX. Kelly, J., et al. "Screening for subclinical deep‐vein thrombosis." Qjm 94.10 (2001): 511-519.

XXX. Kahn, Susan R., et al. "A randomized management study of impedance plethysmography vs. contrast venography in patients with a first episode of clinically suspected deep vein thrombosis." Thrombosis research 102.1 (2001): 15-24.

XXXI. Locker, Thomas, et al. "Meta-analysis of plethysmography and rheography in the diagnosis of deep vein thrombosis." Emergency medicine journal 23.8 (2006): 630-635.

XXXII. Tortoledo, Francisco, Leonardo Izaguirre, and Marı́a Alejandra Tortoledo. "Experiences and controversies related to the endovascular treatment of renovascular hypertension." International Congress Series. Vol. 1237. Elsevier, 2002.

XXXIII. Shahzad, Ghazala, et al. "Diagnostic Accuracy of Color Doppler Ultrasonography among Patients Having Deep Vein Thrombosis by Taking Venography as Gold Standard." Journal of Pharmaceutical Research International (2020): 1-5.

XXXIV. Wakefield, Thomas W., and Lazar J. Greenfield. "Diagnostic approaches and surgical treatment of deep venous thrombosis and pulmonary embolism." Hematology/Oncology Clinics 7.6 (1993): 1251-1267.

XXXV. Needleman, Laurence, et al. "Ultrasound for lower extremity deep venous thrombosis: multidisciplinary recommendations from the Society of Radiologists in Ultrasound Consensus Conference." Circulation 137.14 (2018): 1505-1515.

XXXVI. Planes, A., and N. Vochelle. "Anticoagulants and orthopedic surgery." Anticoagulation. Springer, New York, NY, 1994. 391-413.

XXXVII. Streiff, M. B., Agnelli, G., Connors, J. M., Crowther, M., Eichinger, S., Lopes, R., McBane, R. D., Moll, S., & Ansell, J. (2016). Guidance for the treatment of deep vein thrombosis and pulmonary embolism. Journal of thrombosis and thrombolysis, 41(1), 32–67. https://doi.org/10.1007/s11239-015-1317-0

XXXVIII. Paydar, S., Sabetian, G., Khalili, H., Fallahi, J., Tahami, M., Ziaian, B., Abbasi, H. R., Bolandparvaz, S., Ghaffarpasand, F., & Ghahramani, Z. (2016). Management of Deep Vein Thrombosis (DVT) Prophylaxis in Trauma Patients. Bulletin of emergency and trauma, 4(1), 1–7.

XXXIX. Kakkos, S. K., Caprini, J. A., Geroulakos, G., Nicolaides, A. N., Stansby, G., Reddy, D. J., & Ntouvas, I. (2016). Combined intermittent pneumatic leg compression and pharmacological prophylaxis for prevention of venous thromboembolism. The Cochrane database of systematic reviews, 9(9), CD005258. https://doi.org/10.1002/14651858.CD005258.pub3

XL. Lippi, G., Favaloro, E. J., & Cervellin, G. (2011, April). Prevention of venous thromboembolism: focus on mechanical prophylaxis. In Seminars in thrombosis and hemostasis (Vol. 37, No. 03, pp. 237-251). © Thieme Medical Publishers.

XLI. Shackford, S. R., Davis, J. W., Hollingsworth-Fridlund, P., Brewer, N. S., Hoyt, D. B., & Mackersie, R. C. (1990). Venous thromboembolism in patients with major trauma. American journal of surgery, 159(4), 365–369. https://doi.org/10.1016/s0002-9610(05)81272-3

XLII. Capper, C. (1999). External pneumatic compression therapy for DVT prophylaxis. British Journal of Theatre Nursing, 9(3), 109.

XLIII. Turnbull B. (2007). Prevention of DVT after orthopaedic surgery: the A-V Impulse System. British journal of nursing (Mark Allen Publishing), 16(10), 612–615. https://doi.org/10.12968/bjon.2007.16.10.23509

XLIV. Do, E. J., Lenzini, P., Eby, C. S., Bass, A. R., Mcmillin, G. A., Stevens, S. M., . . . Gage, B. F. (2012). Genetics informatics trial (GIFT) of warfarin to prevent deep vein thrombosis (DVT): Rationale and study design. The Pharmacogenomics Journal, 12(5), 417-24. doi: https://doi.org/10.1038/tpj.2011.18

XLV. Tadros, R., & Shakib, S. (2010). Warfarin: Indications, risks and drug interactions. Australian family physician, 39(7), 476-479.

XLVI. Wadhera, R. K., Russell, C. E., & Piazza, G. (2014). Warfarin versus novel oral anticoagulants: how to choose? Circulation, 130(22), e191-e193.

XLVII. Leyvraz, P. F., Bachmann, F., Hoek, J., Büller, H. R., Postel, M., Samama, M., & Vandenbroek, M. D. (1991). Prevention of deep vein thrombosis after hip replacement: randomised comparison between unfractionated heparin and low molecular weight heparin. British Medical Journal, 303(6802), 543-548.

XLVIII. Harenberg J. (2003). Thrombosetherapie mit niedermolekularem HeparinVergleich von körpergewichtsadjustierter mit fixer Dosierung [Treatment of thrombosis with low-molecular-weight heparin. Comparison of body weight-adjusted and fixed dosage]. Medizinische Klinik (Munich, Germany: 1983), 98(9), 493–498. https://doi.org/10.1007/s00063-003-1290-9

XLIX. Leyvraz, P. F., M.D., Richard, J., M.D., Bachmann, F., M.D., van Melle, G., PhD, Treyvaud, J., M.D., Livio, J., M.D., & Candardjis, G., M.D. (1983). Adjusted versus fixed-dose subcutaneous heparin in the prevention of deep-vein thrombosis after total hip replacement. The New England Journal of Medicine, 309(16), 954-958.

L. Horbach, T., Wolf, H., Michaells, H. C., Wagner, W., Hoffmann, A., Schmidt, A., & Beck, H. (1996). A fixed-dose combination of low molecular weight heparin with dihydroergotamine versus adjusted-dose unfractionated heparin in the prevention of deep-vein thrombosis after total hip replacement. Thrombosis and haemostasis, 75(02), 246-250.

LI. Sobieraj, D. M., Coleman, C. I., Tongbram, V., Chen, W., Colby, J., Lee, S., ... & White, C. M. (2012). Comparative effectiveness of low‐molecular‐weight heparins versus other anticoagulants in major orthopedic surgery: a systematic review and meta‐analysis. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 32(9), 799-808.

LII. Levine, M., Gent, M., Hirsh, J., Leclerc, J., Anderson, D., Weitz, J., ... & Willan, A. (1996). A comparison of low-molecular-weight heparin administered primarily at home with unfractionated heparin administered in the hospital for proximal deep-vein thrombosis. New England Journal of Medicine, 334(11), 677-681.

LIII. Turhan, S., Karaarslan, K., & Abud, B. (2021). The usage and outcomes of dextran in the treatment of acute deep venous thrombosis. Vascular, , 17085381211067039.

LIV. Collaborative overview of randomised trials of antiplatelet therapy--III: Reduction in venous thrombosis and pulmonary embolism by antiplatelet prophylaxis among surgical and medical patients. antiplatelet trialists' collaboration. (1994). BMJ. British Medical Journal (Clinical Research Ed.), 308(6923), 235.

LV. Khai, T., Mary-Doug, W., & Melissa, S. (2020). Acetylsalicylic Acid for Venous Thromboembolism Prophylaxis in Total Hip or Knee Replacement: A Review of Clinical Effectiveness and Guidelines. Canadian Agency for Drugs and Technologies in Health.

LVI. Imperiale, T. F., & Speroff, T. (1994). A meta-analysis of methods to prevent venous thromboembolism following total hip replacement. Jama, 271(22), 1780-1785.

LVII. Kassaï, B., Boissel, J. P., Cucherat, M., Sonie, S., Shah, N. R., & Leizorovicz, A. (2004). A systematic review of the accuracy of ultrasound in the diagnosis of deep venous thrombosis in asymptomatic patients. Thrombosis and haemostasis, 91(04), 655-666.

LVIII. Davidson, B. L., Elliott, C. G., Lensing, A. W., & RD Heparin Arthroplasty Group*>. (1992). Low accuracy of color Doppler ultrasound in the detection of proximal leg vein thrombosis in asymptomatic high-risk patients. Annals of internal medicine, 117(9), 735-738.

LIX. Grady-Benson, J. C., Oishi, C. S., Hanson, P. B., Colwell Jr, C. W., Otis, S. M., & Walker, R. H. (1994). Postoperative surveillance for deep venous thrombosis with duplex ultrasonography after total knee arthroplasty. The Journal of Bone and Joint surgery. American Volume, 76(11), 1649-1657.

LX. Marcucci M., Di Muria Gv, Di Bella L., Lazzara D. (1995) Validity of venous color Doppler in the prevention of thromboembolic disease after total hip replacement. Work in progress of publication on Acts VIII National Congress SPIGC 1995.

LXI. EINSTEIN Investigators, Bauersachs, R., Berkowitz, S. D., Brenner, B., Buller, H. R., Decousus, H., Gallus, A. S., Lensing, A. W., Misselwitz, F., Prins, M. H., Raskob, G. E., Segers, A., Verhamme, P., Wells, P., Agnelli, G., Bounameaux, H., Cohen, A., Davidson, B. L., Piovella, F., & Schellong, S. (2010). Oral rivaroxaban for symptomatic venous thromboembolism. The New England journal of medicine, 363(26), 2499–2510. https://doi.org/10.1056/NEJMoa1007903

LXII. Lyon, C., Mathern, S., Devitt, J., & DeSanto, K. (2017). Rivaroxaban vs. Warfarin for Treatment of DVT and PE. American family physician, 96(8), 532–533.