Therapeutic Effect of Green Synthesized Mno2 Nanoparticles for Treatment of Hyperbilirubinemia -An in-Vivo Study

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Published: Mar 10, 2022
DOI: https://doi.org/10.47191/ijpbms/v2-i3-02
Keywords:
Solanum lycopersicum, Green Synthesis, Nanoparticle, Jaundice, Total Bilirubin, LFT.

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Satarupa Bhattacherjee
Department of Human Physiology with Community Health, Vidyasagar University, Paschim Medinipur, 721102, West Bengal, India
Munmun Bardhan
Department of Physics, Jadavpur University, 188/Raja Subodh Chandra Mullick Road, Jadavpur, Kolkata 700032, India.
Aniruddha Banerjee
Department of Veterinary and Pathology West Bengal University of Animal and Fishery Sciences 700037 West Bengal, India
Madhureema Dey
Department of Physics, Jadavpur University, 188/Raja Subodh Chandra Mullick Road, Jadavpur, Kolkata 700032, India.
Ruma Basu
Department of Physics, Jogamaya Devi College, 26 S.P.Mukherjee Road, Kolkata 700026, India
Sukhen Das
Department of Physics, Jadavpur University, 188/Raja Subodh Chandra Mullick Road, Jadavpur, Kolkata 700032, India.
Sandip Kumar Sinha
Department of Human Physiology with Community Health, Vidyasagar University, Paschim Medinipur, 721102, West Bengal, India

Abstract

Green synthesized manganese oxide (MnO2) nano-conjugate have been widely used as biomedicine in different medical applications. Solanum lycopersicum (Tomato) extract is used to synthesizes MnO2 nanoparticles following a green route, and the synthesized nanoparticles is characterized by XRD, FTIR, UV-Vis, SEM, and later on applied for the evaluation of hepato-protective and anti-oxidant activities in mice. Biochemical tests such as bilirubin, liver function test (LFT), hematological parameters provide evidences for high and non-toxic efficacy of green synthesized nanomaterials in the symptomatic treatment of  hepatic damage. Histopathological changes in liver were investigated in presence of the synthesized nanoconjugate and compared with conventional drug. These results suggest that these green synthesized nanomaterials could appear as an important ameliorative agent and effective for jaundice as well as other related hepatic disorders and could be developed as safe and efficient alternatives to conventional drugs.

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How to Cite
Satarupa Bhattacherjee, Munmun Bardhan, Aniruddha Banerjee, Madhureema Dey, Ruma Basu, Sukhen Das, & Sandip Kumar Sinha. (2022). Therapeutic Effect of Green Synthesized Mno2 Nanoparticles for Treatment of Hyperbilirubinemia -An in-Vivo Study. International Journal of Pharmaceutical and Bio Medical Science, 2(3), 33–42. https://doi.org/10.47191/ijpbms/v2-i3-02
Issue
Vol. 2 No. 3 (2022): Volume 02 Issue 03 March 2022
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Articles
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This work is licensed under a Creative Commons Attribution 4.0 International License.

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