Hypoglycemia-Induced Loss of Consciousness in an Immobilized Geriatric Patient: A Case Report
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Abstract
Introduction : Hypoglycemia in geriatric people is a less well recognized condition and have been correlated with acute outcomes such as seizure, coma, and cardiac arrhythmia. Symptoms of hypoglycemia tend to be less specific with ageing, where diagnosing these conditions in geriatric patient potentially becomes more difficult.
Case Report : A 77-year-old man was brought to the ER due to unresponsive since 2 hours before admission. He was hypoglycemic with a plasma glucose level of 70 mg/dL, hypoalbuminemia (2,6 g/dL), and hyponatremia (121 mmol/L). After receiving intravenous dextrose, he regained consciousness and his plasma glucose level increased to 120 mg/dL. Electrolyte abnormalities were corrected, plasma glucose level monitored every 2 hours and titrated according to hypoglycemia standard procedure. He has been in total bed rest and immobilized for 5 years due to inferior paraparesis with decubitus ulcer, had a history of uncontrolled hypertension and diabetes mellitus. Physical examination showed reduced motor function in his lower extremities. The patient had significant recovery during the treatment course and was discharge 4 days after initial presentation.
Discussion : Hypoglycemia is a low plasma glucose concentration state that could leads to defective glucose counter-regulation and hypoglycemia unawareness. The patient’s long immobilized state potentially leads to a catabolic state that results in muscle wasting. While his reduced intake leads to geriatric anorexia and become the potential cause of hypoglycemia. Mainstay of hypoglycemic treatment is the detection and treatment using interventions that rapidly increased blood sugar to a safe level, eliminating injury risks and quickly relived symptoms.
Conclusion : Diabetes in geriatric has a higher risk for hypoglycemia and should be considered in treating an elderly patient presenting with unresponsiveness or loss of consciousness.
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References
I. Nakhleh A, Shehadeh N. Hypoglycemia in diabetes: An update on pathophysiology, treatment, and prevention. World J Diabetes. 2021;12(12):2036–49. doi:10.4239/wjd.v12.i12.2036
II. Mordarska K, Godziejewska-Zawada M. Diabetes in the elderly. Prz menopauzalny = Menopause Rev. 2017 Jun;16(2):38–43. doi:10.5114/pm.2017.68589
III. Abdelhafiz AH, Rodríguez-Mañas L, Morley JE, Sinclair AJ. Hypoglycemia in older people - A less well recognized risk factor for frailty. Aging Dis. 2015;6(2):156–67. doi:10.14336/AD.2014.0330
IV. Preston J, Biddell B. The physiology of ageing and how these changes affect older people. Med (United Kingdom) [Internet]. 2021;49(1):1–5. doi:10.1016/j.mpmed.2020.10.011 Available from: https://doi.org/10.1016/j.mpmed.2020.10.011
V. Badrkhahan SZ, Ala M, Fakhrzadeh H, Yaghoobi A, Mirzamohamadi S, Arzaghi SM, et al. The prevalence and predictors of geriatric giants in community-dwelling older adults: a cross-sectional study from the Middle East. Sci Rep [Internet]. 2023;13(1):12401. doi:10.1038/s41598-023-39614-4 Available from: https://doi.org/10.1038/s41598-023-39614-4
VI. Greenstein L, Abraham A, Tipping B. Treating complexity in the older adult - the role of the geriatric giants. South African Fam Pract. 2019 Dec 9;61. doi:10.4102/safp.v61i6.5065
VII. Pettus JH, Zhou FL, Shepherd L, Preblick R, Hunt PR, Paranjape S, et al. Incidences of Severe Hypoglycemia and Diabetic Ketoacidosis and Prevalence of Microvascular Complications Stratified by Age and Glycemic Control in U.S. Adult Patients With Type 1 Diabetes: A Real-World Study. Diabetes Care. 2019 Dec;42(12):2220–7. doi:10.2337/dc19-0830
VIII. Yale JF, Breay P, Senior PA. Hypoglycemia: Canada Clinical Practice Guidelines Expert Committee. Can J Diabetes [Internet]. 2018;42:S104–8. Available from: https://doi.org/10.1016/j.jcjd.2017.10.007
IX. Wong CW. Avoiding hypoglycaemia: A new target of care for elderly diabetic patients. Hong Kong Med J. 2015;21(5):444–54. doi:10.12809/hkmj144494
X. Liamis G, Liberopoulos E, Barkas F, Elisaf M. Diabetes mellitus and electrolyte disorders. World J Clin cases. 2014 Oct;2(10):488–96. doi:10.12998/wjcc.v2.i10.488
XI. Brock F, Bettinelli LA, Dobner T, Stobbe JC, Pomatti G, Telles CT. Prevalence of hypoalbuminemia and nutritional issues in hospitalized elders. Rev Lat Am Enfermagem. 2016 Aug;24:e2736. doi:10.1590/1518-8345.0260.2736
XII. NOMURA T, KAWAE T, KATAOKA H, IKEDA Y. Aging, physical activity, and diabetic complications related to loss of muscle strength in patients with type 2 diabetes. Phys Ther Res. 2018;21(2):33–8. doi:10.1298/ptr.r0002
XIII. Rahimi M, Saadat P, Hosseini SR, Bayani MA, Bijani A. Muscle strength in diabetics compared to non-diabetic elderly subjects: A cross sectional and case-control study. Casp J Intern Med. 2019;10(3):265–70. doi:10.22088/cjim.10.3.265
XIV. Marmonti E, Busquets S, Toledo M, Ricci M, Bria J, Oliva F, et al. Immobilization in diabetic rats results in altered glucose tolerance A model of reduced locomotion/activity in diabetes. JCSM Rapid Commun [Internet]. 2018 Jul 1;1(2):1–15. doi:https://doi.org/10.1002/j.2617-1619.2018.tb00007.x Available from: https://doi.org/10.1002/j.2617-1619.2018.tb00007.x
XV. Landi F, Calvani R, Tosato M, Martone AM, Ortolani E, Savera G, et al. Anorexia of Aging: Risk Factors, Consequences, and Potential Treatments. Nutrients. 2016 Jan;8(2):69. doi:10.3390/nu8020069
XVI. Sharifi Y, Ebrahimpur M, Tamehrizadeh SS. Hypoglycemic unawareness: challenges, triggers, and recommendations in patients with hypoglycemic unawareness: a case report. J Med Case Rep [Internet]. 2022;16(1):1–6. doi:10.1186/s13256-022-03498-1 Available from: https://doi.org/10.1186/s13256-022-03498-1
XVII. Kiefer M V, Gene Hern H, Alter HJ, Barger JB. Dextrose 10% in the treatment of out-of-hospital hypoglycemia. Prehosp Disaster Med. 2014 Apr;29(2):190–4. doi:10.1017/S1049023X14000284
XVIII. Yuriani Y, Andrajati R, Pramono LA. Comparison of Effects of The Hypoglycemia Management Protocol with 40% Dextrose Concentrated Solution to the Post-Correction Blood Sugar Response through Intravenous Infusion and Intravenous Bolus. Indones J Clin Pharm. 2019;8(2):99. doi:10.15416/ijcp.2019.8.2.99Nakhleh A, Shehadeh N. Hypoglycemia in diabetes: An update on pathophysiology, treatment, and prevention. World J Diabetes. 2021;12(12):2036–49. doi:10.4239/wjd.v12.i12.2036