Reversible Cholinesterase Inhibitor Loaed Chitosan Based Nanoparticle

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Published: Mar 22, 2023
DOI: https://doi.org/10.47191/ijpbms/v3-i3-07
Keywords:
Ionotropic gelation method; chitosan based nasal drug delivery system; in situ gel system evaluation; in-situ polymeric gel formulation, Mamentine HCl

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Dr. Subhasri Mohapatra
Professor, Royal College of Pharmacy Raipur, Chattishgarh, India

Abstract

Memantine hydrochloride is a is a reversible cholinesterase inhibitor used in the treatment of Alzheimer’s disease, low-moderate affinity, uncompetitive n-methyl-d-aspartate (NMDA) receptor antagonist, with strong voltage dependency and rapid blocking/unblocking kineticsThe present study was explore the potential of mamentine loaded nanoparticle.with varying quantity of chitosan byionotropic gelation method.The effect of chitosan quantity on the particle size was studied by varying stirring time and stirring speed. The particle morphology can be modulated by selecting the agitation speed as well as drug polymer ratio In the present study.The evaluation parameters like Zeta potential, Entrapment efficiency and Poly dispersity index,of optimized formulation CN15 was found to be 364.2±3.37, -8.46, 79.9±0.2 sand 0.283± 0.048 respectively Determination of percentage yield and loading  efficiency,in vitro drug release was also found optimum en 99-100%.

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How to Cite
Mohapatra, D. S. . (2023). Reversible Cholinesterase Inhibitor Loaed Chitosan Based Nanoparticle. International Journal of Pharmaceutical and Bio Medical Science, 3(3), 130–136. https://doi.org/10.47191/ijpbms/v3-i3-07
Issue
Vol. 3 No. 3 (2023): Volume 03 Issue 03 March 2023
Section
Articles
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This work is licensed under a Creative Commons Attribution 4.0 International License.

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